C
avg is the average concentration of a drug in the
central circulation during a dosing interval in
steady state
In systems theory, a system or a Process theory, process is in a steady state if the variables (called state variables) which define the behavior of the system or the process are unchanging in time. In continuous time, this means that for those p ...
. It is calculated by
:
where
is the
area under the curve
In mathematics, an integral assigns numbers to functions in a way that describes displacement, area, volume, and other concepts that arise by combining infinitesimal data. The process of finding integrals is called integration. Along with ...
and
the dosing interval.
See also
*
Area under the curve (pharmacokinetics) In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography–mass spectrometry). In practice, the drug ...
*
Cmax (pharmacology)
References
Pharmacokinetic metrics
{{Pharmacology-stub